This talk, Tuesday (April 9) from 12:30 -1:30 p.m. in 325 Brooks Hall, provides an overview of the Python Spatial Analysis Library. The original motivation for and development of PySAL are described, and the current and future plans for the library are outlined. The talk also uses the history of the project as a lens on wider developments in the area of open source and open science and considers the intersection of geography and regional science with these currents. Opportunities that the emerging fields of data science and analytics afford for spatial and regional science are identified, and exemplar efforts leading the charge in engaging with these opportunities are highlighted.